Cytosolic RNA:DNA hybrids activate the cGAS–STING axis. (25th November 2014)

• Record Type: Journal Article
• Authors: Mankan, Arun K; Schmidt, Tobias; Chauhan, Dhruv; Goldeck, Marion; Höning, Klara; Gaidt, Moritz; Kubarenko, Andrew V; Andreeva, Liudmila; Hopfner, Karl‐Peter; Hornung, Veit
• Is Part Of: EMBO journal. Volume 33:Number 24(2014)
• Page Start: 2937
• Page End: 2946
• Publication Date: 2014-11-25
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201488726
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="embj201488726-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>RNA:DNA hybrids are a novel class of intracellular PAMP molecules that can directly stimulate cGAS to produce cGAMP leading to the induction of antiviral response genes. <boxed-text content-type="graphic" id="embj201488726-blkfxd-0002" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2t483f7c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>