MIC gene polymorphism and haplotype diversity in Li nationality of Southern China. Issue 1 (2nd December 2014)

• Record Type: Journal Article
• Authors: Lin, L.; Yang, W.; Chen, E.; Gong, Z.; Luo, Q. Z.; Wei, X. B.; Yu, P.
• Is Part Of: Tissue antigens. Volume 85:Issue 1(2015)
• Page Start: 45
• Page End: 49
• Publication Date: 2014-12-02
• Subjects: Antigens -- Periodicals; Immunological tolerance -- Periodicals; Immunogenetics -- Periodicals; 571.9645
• DOI: 10.1111/tan.12449
• Languages: English
• ISSNs: 0001-2815

Abstract

<abstract abstract-type="main" id="tan12449-abs-0001"> <title>Abstract</title> <p id="tan12449-para-0001">Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Li population of 344 unrelated individuals. By using polymerase chain reaction‐sequence specific priming (PCR‐SSP) and sequence‐based typing (PCR‐SBT), 17 MICA‐sequence alleles and 5 MICA‐STR (short tandem repeats, STR) alleles, as well as 17 MICB alleles were detected, among which <italic>MICA*010</italic>, <italic>MICA*A4</italic> and <italic>MICB*005:02</italic> were the most frequent alleles. In addition, linkage disequilibrium was investigated and the most common two‐locus haplotypes were <italic>MICB*005:02‐MICA*010</italic> and <italic>MICB*008‐MICA*002:01</italic>. These results present informative genetic markers for the investigation of possible origins and the evolution of MHC class I haplotypes in the Li population.</p> </abstract>