Differential Cytokine Expression in Natural and Experimental Mastitis Induced by Mycoplasma agalactiae in Dairy Goats. Issue 1 (15th November 2014)

• Record Type: Journal Article
• Authors: Rodríguez, F; Castro, P
• Is Part Of: Reproduction in domestic animals. Volume 50:Issue 1(2015)
• Page Start: 159
• Page End: 163
• Publication Date: 2014-11-15
• Subjects: Animal breeding -- Periodicals; Veterinary pathology -- Periodicals; Livestock -- Breeding -- Periodicals; 636.082
• DOI: 10.1111/rda.12457
• Languages: English
• ISSNs: 0936-6768

Abstract

<abstract abstract-type="main" id="rda12457-abs-0001"> <title>Contents</title> <p>Cytokines, primarily produced by macrophages and lymphocytes, mobilize the immune system in response to infection, particularly at mucosal surfaces. Knowledge of the pathogenesis and persistence of <italic>Mycoplasma agalactiae</italic> (<italic>Ma</italic>) in the mammary gland is still insufficient. The aim of this study was to elucidate the role of cytokines in the pathogenesis of caprine mastitis caused by <italic>Ma</italic>. Cytokine expression was evaluated by immunohistochemical methods in the inflammatory lesions of 10 (5 naturally and 5 experimentally infected) goats with <italic>Ma</italic>‐induced mastitis. Immunolabelling for IL‐10, IFN‐γ, IL‐4 and TNF‐α was observed in inflammatory cells within the lumen of acini and ducts and in the interstitial spaces and was usually associated with the presence of <italic>Ma</italic> antigen. The results suggest that cytokines play a role in the pathophysiological processes during <italic>Ma</italic> infection as differential expression of these cytokines was detected in relation to the course of the infection.</p> </abstract>