Lower Blood Pressure and Apathy Coincide in Older Persons with Poorer Functional Ability: The Discontinuation of Antihypertensive Treatment in Elderly People (DANTE) Study Leiden. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Moonen, Justine E. F.; Bertens, Anne Suzanne; Foster‐Dingley, Jessica C.; Smit, Roelof A. J.; van der Grond, Jeroen; de Craen, Anton J. M.; de Ruijter, Wouter; van der Mast, Roos C.
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 1(2015:Jan.)
• Page Start: 112
• Page End: 117
• Publication Date: 2015-01
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13199
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13199-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13199-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the association between blood pressure (BP) measures and symptoms of apathy and depression in older adults with various levels of functional ability.</p> </sec> <sec id="jgs13199-sec-0002" sec-type="section"> <title>Design</title> <p>Cross‐sectional study using baseline data from the Discontinuation of Antihypertensive Treatment in Elderly people (DANTE) Study Leiden.</p> </sec> <sec id="jgs13199-sec-0003" sec-type="section"> <title>Setting</title> <p>Primary care setting, the Netherlands.</p> </sec> <sec id="jgs13199-sec-0004" sec-type="section"> <title>Participants</title> <p>Community‐dwelling individuals aged 75 and older (N = 430).</p> </sec> <sec id="jgs13199-sec-0005" sec-type="section"> <title>Measurements</title> <p>Systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) were measured during home visits. Symptoms of apathy and depression were assessed using the Apathy Scale and the Geriatric Depression Scale (GDS‐15), respectively. Stratified linear regression was performed in participants with better and worse functional ability according to the median of the Groningen Activity Restriction Scale.</p> </sec> <sec id="jgs13199-sec-0006" sec-type="section"> <title>Results</title> <p>In participants with lower functional ability, each 10‐mmHg lower SBP, DBP, and MAP was associated with higher Apathy Scale scores (0.63, 0.92, and 0.94 points, respectively, all <italic>P</italic> < .005) but not with GDS‐15 scores. In participants with higher functional ability, BP measures were not associated with Apathy Scale or GDS‐15 scores.</p> </sec> <sec id="jgs13199-sec-0007" sec-type="section"> <title>Conclusion</title> <p>In older participants with poorer functional ability, lower BP was associated with more symptoms of apathy but not depression.</p> </sec> </abstract>