Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats. (13th January 2015)

• Record Type: Journal Article
• Authors: Fügl, Alexander; Gruber, Reinhard; Agis, Hermann; Lzicar, Hannah; Keibl, Claudia; Schwarze, Uwe Yacine; Dvorak, Gabriella
• Is Part Of: Journal of clinical periodontology. Volume 42:Number 1(2015:Jan.)
• Page Start: 96
• Page End: 103
• Publication Date: 2015-01-13
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12342
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12342-abs-0001"> <title>Abstract</title> <sec id="jcpe12342-sec-0001" sec-type="section"> <title>Aim</title> <p>Vitamin D deficiency is considered to diminish bone regeneration. Yet, raising the serum levels takes months. A topic application of the active vitamin D metabolite, calcitriol, may be an effective approach. Thus, it becomes important to know the effect of vitamin D deficiency and local application on alveolar bone regeneration.</p> </sec> <sec id="jcpe12342-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Sixty rats were divided into three groups; two vitamin depletion groups and a control group. Identical single defects (2 mm diameter) were created in the maxilla and mandible treated with calcitriol soaked collagen in one deficiency group while in the other two groups not. Histomorphometric analysis and micro CTs were performed after 1 and 3 weeks. Serum levels of 25(OH)D<sub>3</sub> and PTH were determined.</p> </sec> <sec id="jcpe12342-sec-0003" sec-type="section"> <title>Results</title> <p>Bone formation rate significantly increased within the observation period in all groups. Bone regeneration was higher in the maxilla than in the mandible. However, bone regeneration was lower in the control group compared to vitamin depletion groups, with no significant effects by local administration of calcitriol (micro CT mandible <italic>p</italic> = 0.003, maxilla <italic>p</italic> < 0.001; histomorphometry maxilla <italic>p</italic> = 0.035, mandible <italic>p</italic> = 0.18).</p> </sec> <sec id="jcpe12342-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Vitamin D deficiency not necessarily impairs bone regeneration in the rat jaw and a single local calcitriol application does not enhance healing.</p> </sec> </abstract>