Association analysis of the GRM8 gene with schizophrenia in the Uygur Chinese population. Issue 6 (December 2014)

• Record Type: Journal Article
• Authors: Zhang, Lili; Zhong, Xianjiang; An, Zhiguo; Han, Shuxian; Luo, Xiao; Shi, Yongyong; Yi, Qizhong
• Is Part Of: Hereditas. Volume 151:Issue 6(2014:Dec.)
• Page Start: 140
• Page End: 144
• Publication Date: 2014-12
• Subjects: Heredity -- Periodicals; Genetics -- Periodicals; Cytogénétique; Génétique; Hérédité; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 576.5
• DOI: 10.1111/hrd2.00045
• Languages: English
• ISSNs: 0018-0661

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>GRM8</italic> is a schizophrenia candidate gene that is also thought to be involved in the glutamate pathway, which is very important in the pathogenesis of schizophrenia. In this study, we aim to investigate the association between <italic>GRM8</italic> and schizophrenia in the Uygur Chinese population.</p> <p>Rs2237748 and rs2299472, located in the <italic>GRM8</italic> gene, were selected for genotyping in a set of Uygur Chinese case‐control samples, which included 723 cases and 561 controls, using TaqMan assays and capillary sequencing. The statistical analysis was carried out using the online software program SHEsis, and a meta‐analysis was carried out to identify other relevant studies using Review Manager 5. We found that the rs2299472 genotype was significantly associated with schizophrenia (P = 0.015, P = 0.030, after Bonferroni correction). The frequency of the CC genotype was higher in the schizophrenic patients (P = 0.008), and the frequency of the AC genotype was lower (P = 0.008). Furthermore, the meta‐analysis incorporating the previous and current studies also showed that rs2299472 is associated with schizophrenia. This study indicates that the <italic>GRM8</italic> gene may play an important role in the pathogenesis of schizophrenia.</p> </abstract>