Influence of male hyperinsulinaemia on IVF outcome. (23rd January 2014)

• Record Type: Journal Article
• Authors: Bosman, E.; Esterhuizen, A. D.; Rodrigues, F. A.; Becker, P.; Hoffmann, W. A.
• Is Part Of: Andrologia. Volume 47:Number 1(2015)
• Page Start: 91
• Page End: 96
• Publication Date: 2014-01-23
• Subjects: Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12227
• Languages: English
• ISSNs: 0303-4569

Abstract

<abstract abstract-type="main" id="and12227-abs-0001"> <title>Summary</title> <p>The IVF outcome of a group of hyperinsulinaemic men (group B) was compared with a group of IVF males with normal insulin levels (group A). The participating females in the study groups were younger than 38 years old, had blocked Fallopian tubes and/or endometriosis, had normal insulin levels and produced five or more ova on stimulation. The male participants in both groups were normozoospermic with motility above 50% and sperm morphology between 5 and 13% normal forms (G‐pattern according to Tygerberg strict criteria). The two groups did not differ statistically in terms of age or semen parameters (<italic>P</italic> = 0.39; <italic>P</italic> &lt; 0.05).The group of men that presented with normal insulin levels had a higher fertilisation rate (79.15% versus 74.57%) and superior embryo quality on day 3 (55.77% versus 50.39%) than the group that presented with hyperinsulinaemia, but these differences were not statistically significant (<italic>P</italic> = 0.28, <italic>P</italic> = 0.40; <italic>P</italic> &lt; 0.05). The clinical pregnancy rate of the group with normal insulin was significantly higher than that of the hyperinsulinaemic group, 57.9% versus 31.8% respectively (<italic>P</italic> = 0.03). The results suggest that hyperinsulinaemia had a negative impact on IVF outcome and patients should be advised accordingly.</p> </abstract>