Dynamic inversion time for improved 3D late gadolinium enhancement imaging in patients with atrial fibrillation. Issue 2 (6th March 2014)

• Record Type: Journal Article
• Authors: Keegan, Jennifer; Gatehouse, Peter D.; Haldar, Shouvik; Wage, Ricardo; Babu‐Narayan, Sonya V.; Firmin, David N.
• Is Part Of: Magnetic resonance in medicine. Volume 73:Issue 2(2015:Feb.)
• Page Start: 646
• Page End: 654
• Publication Date: 2014-03-06
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25190
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25190-sec-0001" sec-type="section"> <title>Purpose</title> <p>High resolution three‐dimensional (3D) late gadolinium enhancement (LGE) imaging is performed with single R‐wave gating to minimize lengthy acquisition durations. In patients with atrial fibrillation (AF), heart rate variability results in variable magnetization recovery between sequence repeats, and image quality is often poor. In this study, we implemented and tested a dynamic inversion time (dynamic‐TI) scheme designed to reduce sequence sensitivity to heart rate variations.</p> </sec> <sec id="mrm25190-sec-0002" sec-type="section"> <title>Methods</title> <p>An inversion‐prepared 3D segmented gradient echo sequence was modified so that the TI varied automatically from beat‐to‐beat (dynamic‐TI) based on the time since the last sequence repeat. 3D LGE acquisitions were performed in 17 patients prior to radio frequency ablation of persistent AF both with and without dynamic‐TI. Qualitative image quality scores, blood signal‐to‐ghosting ratios (SGRs). and blood–myocardium contrast‐to‐ghosting ratios (CGRs) were compared.</p> </sec> <sec id="mrm25190-sec-0003" sec-type="section"> <title>Results</title> <p>Image quality scores were higher with dynamic‐TI than without dynamic‐TI (2.2 ± 0.9 vs. 1.8 ± 1.1, <italic>P</italic> = 0.008), as were blood–myocardium CGRs (13.8 ± 7.6 vs. 8.3 ± 6.1, <italic>P</italic> = 0.003) and blood SGRs (19.6 ± 8.5 vs. 13.1 ± 8.0, <italic>P</italic> = 0.003).</p> </sec> <sec id="mrm25190-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The dynamic‐TI algorithm improves image quality of 3D LGE imaging in this difficult patient population by reducing the sequence sensitivity to RR interval variations <bold>Magn Reson Med 73:646–654, 2015. © 2014 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>