A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity. (25th November 2014)
- Record Type:
- Journal Article
- Title:
- A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity. (25th November 2014)
- Main Title:
- A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
- Authors:
- Kim, Dong‐Hyun
Xiao, Zhen
Kwon, Sanghoon
Sun, Xiaoxiao
Ryerson, Daniel
Tkac, David
Ma, Ping
Wu, Shwu‐Yuan
Chiang, Cheng‐Ming
Zhou, Edward
Xu, H Eric
Palvimo, Jorma J
Chen, Lin‐Feng
Kemper, Byron
Kemper, Jongsook Kim - Abstract:
- <abstract abstract-type="graphical" xml:lang="en" id="embj201489527-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Elevated acetylation of the mouse nuclear Farnesoid X receptor (FXR) in obesity inhibits its SUMOylation, which promotes hepatic inflammation and metabolic dysfunction <italic>in vivo</italic>.<boxed-text content-type="graphic" id="embj201489527-blkfxd-0002" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh31wfmt0d" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>
- Is Part Of:
- EMBO journal. Volume 34:Number 2(2015)
- Journal:
- EMBO journal
- Issue:
- Volume 34:Number 2(2015)
- Issue Display:
- Volume 34, Issue 2 (2015)
- Year:
- 2015
- Volume:
- 34
- Issue:
- 2
- Issue Sort Value:
- 2015-0034-0002-0000
- Page Start:
- 184
- Page End:
- 199
- Publication Date:
- 2014-11-25
- Subjects:
- Molecular biology -- Periodicals
572.805 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.15252/embj.201489527 ↗
- Languages:
- English
- ISSNs:
- 0261-4189
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3733.085000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 3293.xml