Ovarian cavity fluid of the viviparous surfperch Neoditrema ransonnetii suppresses the spontaneous cytotoxic activity of head‐kidney leucocytes against xenogeneic targets. Issue 1 (January 2015) - Yokozawa, N.
Abstract In this study, the effect of ovarian cavity fluid (OCF) from a surfperch Neoditrema ransonnetii on the cytotoxic activity of leucocytes was investigated. In an assay targeting RTG‐2, a cell line derived from rainbow trout Oncorhynchus mykiss gonads, leucocytes from both the spleen and head kidney showed spontaneous killing activity. Pre‐incubation with OCF significantly suppressed the cytotoxic activity of head‐kidney leucocytes towards RTG‐2. This suppressive activity was due to the presence of low molecular‐mass materials. These results suggest that OCF plays significant roles in pregnancy by its ability to modulate cytotoxicity with maternal leucocytes.