Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization. Issue 1 (8th December 2014)

• Record Type: Journal Article
• Authors: Lee, Chih‐Hung; Chen, Jau‐Shiuh; Chiu, Hsien‐Ching; Hong, Chien‐Hui; Liu, Ching‐Yi; Ta, Yng‐Cun; Clausen, Bjőrn E.; Ho, Ji‐Chen; Wang, Li‐Fang
• Is Part Of: Experimental dermatology. Volume 24:Issue 1(2015:Jan.)
• Page Start: 67
• Page End: 69
• Publication Date: 2014-12-08
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.12583
• Languages: English
• ISSNs: 0906-6705

Abstract

<abstract abstract-type="main" id="exd12583-abs-0001"> <title>Abstract</title> <p>A murine repeated protein‐patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non‐atopy, respectively. In this study, a single protein‐patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin‐DTR mice, we demonstrated that dermal dendritic cells, but not Langerhans cells, are critical in single epicutaneous sensitization in both strains of mice.</p> </abstract>