Frontispiece: An Integrated Imaging Probe Design: The Synthesis of 99mTc/Re‐Containing Macrocyclic Peptide Scaffolds. Issue 2 (7th January 2015)

• Record Type: Journal Article
• Authors: Hickey, Jennifer L.; Simpson, Emily J.; Hou, Jinqiang; Luyt, Leonard G.
• Is Part Of: Chemistry. Volume 21:Issue 2(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-01-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201580262
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Metal Scaffolding</bold> With the proper design, cyclic peptides may act as scaffolds emulating β‐sheet regions, enabling investigation into molecular recognition and protein aggregation. In their Full Paper on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 568 ff., </ext-link> L. G. Luyt et al. report on the synthesis of peptide macrocycles, which have been stitched together through a pyridyl tridentate chelation core, followed by metal coordination using ^99mTc or Re tricarbonyl. Structural analysis revealed that the peptide backbone exists in a similar conformation both before and after metal incorporation.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh30vmshcp" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>