A Preloaded Amorphous Calcium Carbonate/Doxorubicin@Silica Nanoreactor for pH‐Responsive Delivery of an Anticancer Drug1. Issue 3 (24th November 2014)

• Record Type: Journal Article
• Authors: Zhao, Yang; Luo, Zhong; Li, Menghuan; Qu, Qiuyu; Ma, Xing; Yu, Shu‐Hong; Zhao, Yanli
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 3(2015)
• Page Start: 919
• Page End: 922
• Publication Date: 2014-11-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201408510
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH‐responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy.</p> </abstract>