Synthesis and characterisation of porous luminescent glass ceramic scaffolds containing europium for bone tissue engineering. (April 2015)

• Record Type: Journal Article
• Authors: Li, G.; Liang, G.; Zhao, S.; Ma, K.; Feng, W.; Zhou, D.; Liu, X.
• Is Part Of: Advances in applied ceramics. Volume 114:Number 3(2015)
• Page Start: 164
• Page End: 174
• Publication Date: 2015-04
• Subjects: Ceramics -- Periodicals; 620.1405
• DOI: 10.1179/1743676114Y.0000000210
• Languages: English
• ISSNs: 1743-6753

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>Eu₂O₃ was added to bioactive glass ceramic in the system CaO–SiO₂–P₂O₅–MgO–CaF₂ to prepare porous luminescent scaffold with high mechanical property. The crystal structure, compressive strength, <italic>in vitro</italic> bioactivity, cell affinity and luminescent property under ultraviolet of samples was evaluated. According to results, Eu₂O₃ improved the crystallisation behaviour but inhibited fluorapatite formation in the glass ceramics. Although scaffolds had connective porous structure, the compressive strength could be improved to as high as 3·6 MPa with the addition of Eu₂O₃. The <italic>in vitro</italic> bioactivity test showed a decrease in Ca release ability and a retardation of apatite forming on the samples with increasing substitution of Eu₂O₃ for CaO. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay and SEM observation results displayed that ROS17/2·8 cells could attach and differentiate on all the scaffolds. Moreover, the Eu₂O₃ doped scaffolds fluoresced well a red colour under ultraviolet, and a decrease in the emission intensities could be observed after the cell coculturing process.</p> </abstract>