Impact of body mass index on outcomes of laparoscopic radical prostatectomy with long-term follow-up. (February 2015)

• Record Type: Journal Article
• Authors: Gözen, Ali Serdar; Akin, Yigit; Özden, Ender; Ates, Mutlu; Hruza, Marcel; Rassweiler, Jens
• Is Part Of: Scandinavian journal of urology. Volume 49:Number 1(2015:Feb.)
• Page Start: 70
• Page End: 76
• Publication Date: 2015-02
• Subjects: Urology -- Periodicals; 616.6
• DOI: 10.3109/21681805.2014.920416
• Languages: English
• ISSNs: 2168-1805

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective. </italic>The aim of this study was to investigate the impact of body mass index (BMI) on the functional and oncological results of patients who had undergone laparoscopic radical prostatectomy (LRP). <italic>Material and methods.</italic> In total, 1224 patients with follow-up data (>24 months) were enrolled. Patients were divided into three groups according to BMI (kg/m<sup>2</sup>) as: group 1 (normal, BMI <25, <italic>n</italic> = 425), group 2 (overweight, 25 ≤BMI <30, <italic>n</italic> = 594) and group 3 (obese, BMI ≥30, <italic>n</italic> = 205). Demographic, intraoperative and postoperative data with oncological outcomes were recorded. The impact of obesity on those parameters was evaluated and statistical analyses were performed. <italic>Results. </italic>Mean age was 63.8 ± 6.1 years and mean follow-up was 43.1 ± 25.1 months (mean ± SD). There were 425 (34.7%) patients in group 1, 594 (48.5%) in group 2 and 205 (16.8%) in group 3. Operation time, clinical stage and estimated blood loss were significantly higher in group 3 than in the other groups (<italic>p</italic> < 0.001, <italic>p</italic> = 0.001 and <italic>p</italic> = 0.001, respectively). Bilateral nerve-sparing rate and bladder neck-sparing rate were significantly decreased in group 3 compared with the other groups (<italic>p</italic> = 0.001 and <italic>p</italic> < 0.038, respectively). Statistically significantly higher pathological stage, tumour volume, positive surgical margin and Gleason scores were determined in group 3 compared with the other groups (<italic>p</italic> = 0.023, <italic>p</italic> = 0.018, <italic>p</italic> = 0.009 and <italic>p</italic> = 0.028, respectively). There were similar urinary continence rates among the groups. The rate of penetration with or without medication was significantly lower in group 3 than in the other groups (<italic>p</italic> = 0.593 and <italic>p</italic> = 0.007, respectively). <italic>Conclusions. </italic>LRP seemed safe and effective in obese patients, with similar mean overall survival, cancer-specific survival, complication rates and continence rates to normal weight patients in the long term.</p> </abstract>