Genotype I of hepatitis B virus was found in east Xishuangbanna, China and molecular dynamics of HBV/I. Issue 1 (18th February 2014)

• Record Type: Journal Article
• Authors: Shen, T.; Yan, X. M.; Liu, H .X.; Zhang, B. X.; Li, L.; Zhang, J. P.; Wang, J. L.; Xiao, C. J.
• Is Part Of: Journal of viral hepatitis. Volume 22:Issue 1(2015)
• Page Start: 37
• Page End: 45
• Publication Date: 2014-02-18
• Subjects: Hepatitis, Viral -- Periodicals; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; 616.3623
• DOI: 10.1111/jvh.12231
• Languages: English
• ISSNs: 1352-0504

Abstract

<abstract abstract-type="main" id="jvh12231-abs-0001"> <title>Summary</title> <p>There is a dearth of data about the prevalence of hepatitis B virus (HBV) infection in Mengla, China; and no detailed analysis of the molecular evolution of genotype I in Asia. In this study, 909 serum samples from ethnic minority people in China were obtained. Serological assay and HBV S‐gene amplification were carried out, and phylogenetic and evolutionary dynamics analysis of 62 HBV/I S‐gene was performed. On this survey, 153 individuals were tested HBsAg‐positive. Genotypes of S‐gene were classified into three groups: C, B and I. Under the strict model and the relax model, the estimated evolutionary rates for HBV/I were 3.74 × 10⁻⁴ and 6.93 × 10⁻⁴ substitution/site/year, respectively. However, when the geographic origin was taken into account, the mean substitution rates were increased. Estimated time to most recent ancestor of genotype I varied from ~30 to ~70 years ago. The Bayesian sky plot showed a rapid spread of HBV/I at the end of 1980s. Peculiar nucleotides distributed were observed in the subgenotype I1/I2. In conclusion, higher prevalence of HBV infection was observed in Mengla county. Multifactors like timescale and spatial locations should be integrated to provide a better interpretation of the HBV/I evolutionary history in the region.</p> </abstract>