Clinical role of Notch signaling pathway in intraductal papillary mucinous neoplasm of the pancreas. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Ikemoto, Tetsuya; Sugimoto, Koji; Shimada, Mitsuo; Utsunomiya, Tohru; Morine, Yuji; Imura, Satoru; Arakawa, Yusuke; Kanamoto, Mami; Iwahashi, Shu‐ichi; Saito, Yu; Yamada, Shinichiro
• Is Part Of: Journal of gastroenterology and hepatology. Volume 30:Issue 1(2015:Jan.)
• Page Start: 217
• Page End: 222
• Publication Date: 2015-01
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12660
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12660-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>This study was performed to elucidate the expression of the Notch signaling pathway and its correlations to clinicopathological factors of intraductal papillary mucinous neoplasms (IPMNs). It is incontrovertible that regulatory T cells (Tregs) play an important role in tumor immunity. However, the whole mechanism of control of peripheral Tregs remains unclear. It is also known that the Notch signaling pathway is involved in Treg suppressor function. Moreover, IPMNs have a high malignant potential.</p> </sec> <sec id="jgh12660-sec-0002" sec-type="section"> <title>Methods</title> <p>Peripheral blood samples and resected specimens from 18 patients with IPMN were evaluated. All patients were pathologically diagnosed with IPMN. Resected specimens were immunohistochemically evaluated (anti‐Notch1, anti‐Notch2, and anti‐Notch2‐intracellular domain antibody staining) and compared in terms of clinicopathological factors. Peripheral Treg populations were analyzed with an automated flow cytometer.</p> </sec> <sec id="jgh12660-sec-0003" sec-type="section"> <title>Results</title> <p>Disease‐free survival was significantly worse in the Notch1 high‐expression group (<italic>P</italic> = 0.023). Notch2 family expressions were higher in intraductal papillary mucinous carcinoma (IPMC) than in intraductal papillary mucinous adenoma (IPMA) (Notch2, <italic>P</italic> = 0.012; Notch2‐intracellular domain, <italic>P</italic> = 0.036). Jagged1 expression was significantly higher in IPMC than in IPMA (<italic>P</italic> < 0.05) and was significantly related to recurrence. The Treg population in peripheral blood was higher in patients with IPMC than in those with IPMA (<italic>P</italic> < 0.01).</p> </sec> <sec id="jgh12660-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Notch signaling, especially Jagged1 expression, reflects IPMN aggressiveness. Our data may suggest that the Notch signaling pathway is a key pathway that determines IPMN pathological aggressiveness and reflects the peripheral Treg population.</p> </sec> </abstract>