Mosapride treatment for functional dyspepsia: A meta‐analysis. Issue 1 (January 2015)
- Record Type:
- Journal Article
- Title:
- Mosapride treatment for functional dyspepsia: A meta‐analysis. Issue 1 (January 2015)
- Main Title:
- Mosapride treatment for functional dyspepsia: A meta‐analysis
- Authors:
- Bang, Chang Seok
Kim, Jong Hyeok
Baik, Gwang Ho
Kim, Hyo Sun
Park, Sang Hyun
Kim, Eun Jin
Kim, Jin Bong
Suk, Ki Tae
Yoon, Jai Hoon
Kim, Yeon Soo
Kim, Dong Joon - Abstract:
- <abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12662-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>The aim of this study was to assess the therapeutic effect of mosapride in patients with functional dyspepsia (FD).</p> </sec> <sec id="jgh12662-sec-0002" sec-type="section"> <title>Methods</title> <p>Randomized controlled trials (RCTs) of mosapride for the treatment of FD performed between 2002 and 2013 were identified from databases. Symptom response rates were extracted and analyzed using risk ratios (RRs). A random effect model was applied based on Higgins <italic>I</italic><sup>2</sup> tests. Publication bias was evaluated using a funnel plot, Egger's test, trim and fill, and the rank correlation test.</p> </sec> <sec id="jgh12662-sec-0003" sec-type="section"> <title>Results</title> <p>In total, 13 RCTs, which included 1091 mosapride‐treated patients and 1129 control patients (on placebo or other drugs), were identified and analyzed. Overall, mosapride showed an RR of 0.999 (95% confidence interval [CI]: 0.869–1.150, <italic>P</italic> = 0.992) for improving global efficacy or symptom‐based scores. In a sensitivity analysis of the high‐quality RCTs, mosapride showed an RR of 1.114 (95% CI: 1.011–1.227, <italic>P</italic> = 0.029). However, in the studies using the Rome III criteria for the diagnosis of FD, mosapride showed an RR of 0.906 (95% CI: 0.807–1.016, <italic>P</italic> = 0.092). In the studies having funding source,<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12662-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>The aim of this study was to assess the therapeutic effect of mosapride in patients with functional dyspepsia (FD).</p> </sec> <sec id="jgh12662-sec-0002" sec-type="section"> <title>Methods</title> <p>Randomized controlled trials (RCTs) of mosapride for the treatment of FD performed between 2002 and 2013 were identified from databases. Symptom response rates were extracted and analyzed using risk ratios (RRs). A random effect model was applied based on Higgins <italic>I</italic><sup>2</sup> tests. Publication bias was evaluated using a funnel plot, Egger's test, trim and fill, and the rank correlation test.</p> </sec> <sec id="jgh12662-sec-0003" sec-type="section"> <title>Results</title> <p>In total, 13 RCTs, which included 1091 mosapride‐treated patients and 1129 control patients (on placebo or other drugs), were identified and analyzed. Overall, mosapride showed an RR of 0.999 (95% confidence interval [CI]: 0.869–1.150, <italic>P</italic> = 0.992) for improving global efficacy or symptom‐based scores. In a sensitivity analysis of the high‐quality RCTs, mosapride showed an RR of 1.114 (95% CI: 1.011–1.227, <italic>P</italic> = 0.029). However, in the studies using the Rome III criteria for the diagnosis of FD, mosapride showed an RR of 0.906 (95% CI: 0.807–1.016, <italic>P</italic> = 0.092). In the studies having funding source, mosapride showed an RR of 1.131 (95% CI: 1.028–1.244, <italic>P</italic> = 0.012), whereas an RR of 0.966 (95% CI: 0.896–1.042, <italic>P</italic> = 0.367) was observed in the studies without funding source. Publication bias was not detected.</p> </sec> <sec id="jgh12662-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In this analysis, we could not find a significant effect of mosapride on FD. Inconsistent diagnostic criteria for FD and different assessment outcomes are causes of heterogeneity. Further studies using common validated outcomes or questionnaires and high‐quality RCTs will elucidate the real effect of this medication on FD.</p> </sec> </abstract> … (more)
- Is Part Of:
- Journal of gastroenterology and hepatology. Volume 30:Issue 1(2015:Jan.)
- Journal:
- Journal of gastroenterology and hepatology
- Issue:
- Volume 30:Issue 1(2015:Jan.)
- Issue Display:
- Volume 30, Issue 1 (2015)
- Year:
- 2015
- Volume:
- 30
- Issue:
- 1
- Issue Sort Value:
- 2015-0030-0001-0000
- Page Start:
- 28
- Page End:
- 42
- Publication Date:
- 2015-01
- Subjects:
- Gastroenterology -- Periodicals
Digestive organs -- Diseases -- Periodicals
Liver -- Diseases -- Periodicals
Gastroenterology -- Periodicals
Liver Diseases -- Periodicals
616.33 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1746 ↗
http://onlinelibrary.wiley.com/ ↗
http://www.blackwell-synergy.com/loi/jgh ↗ - DOI:
- 10.1111/jgh.12662 ↗
- Languages:
- English
- ISSNs:
- 0815-9319
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4987.615000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 4133.xml