Incidence and survival in late liver metastases of colorectal cancer. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Landreau, Pierre; Drouillard, Antoine; Launoy, Guy; Ortega‐Deballon, Pablo; Jooste, Valérie; Lepage, Côme; Faivre, Jean; Facy, Olivier; Bouvier, Anne‐Marie
• Is Part Of: Journal of gastroenterology and hepatology. Volume 30:Issue 1(2015:Jan.)
• Page Start: 82
• Page End: 85
• Publication Date: 2015-01
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12685
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12685-sec-0001" sec-type="section"> <title>Background and Aims</title> <p>Data concerning the risk of long‐term liver metastasis following surgery of colorectal cancer in the general population are scarce. The 10‐year incidence and prognosis of metachronous liver metastases remain unknown.</p> </sec> <sec id="jgh12685-sec-0002" sec-type="section"> <title>Methods</title> <p>Among 4584 patients resected for cure for colorectal cancer recorded in two French digestive population‐based cancer registries between 1985 and 2000, 602 presented metastases including liver metastases.</p> </sec> <sec id="jgh12685-sec-0003" sec-type="section"> <title>Results</title> <p>The cumulated incidence of liver metastasis was 15% at 5 years and 17% at 10 years, and was mainly related to stage at diagnosis. The 10‐year cumulative incidence was 6% for stage I and 30% for stage III. The hazard ratio was 3.2 [2.4–4.3] for stage II and 6.9 [5.1–9.2] for stage III compared with stage I. Among survivors with no recurrence five years after diagnosis, 2.2% developed liver metastasis between 5 and 10 years. Resection for cure of liver metastases was performed in 35% of patients aged under 75 years and in 10% of patients over 75 (<italic>P</italic> < 0.001). After resection for cure, 10‐year relative survival improved from 21% during the period 1985–1997 to 34% during the period 1998–2011 (<italic>P</italic> = 0.023). Survival in patients with liver metastasis diagnosed between six and 12 months after surgery was less than half that in patients with metastasis diagnosed later (HR: 0.6 [0.4–1.0]).</p> </sec> <sec id="jgh12685-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Liver metastases from colorectal cancer remain a substantial problem and continue to occur long after five years. This study furnishes unbiased figures that can be used as a reference. Liver metastases that appear late have a better prognosis.</p> </sec> </abstract>