Clinical Implications of Basic Science Discoveries: Janus Resurrected—Two Faces of B Cell and Plasma Cell Biology. Issue 1 (7th November 2014)

• Record Type: Journal Article
• Authors: Woodle, E. S.; Rothstein, D. M.
• Is Part Of: American journal of transplantation. Volume 15:Issue 1(2015:Jan.)
• Page Start: 39
• Page End: 43
• Publication Date: 2014-11-07
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.13028
• Languages: English
• ISSNs: 1600-6135

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ajt13028-sec-0001" sec-type="section"> <p>B cells play a complex role in the immune response. In addition to giving rise to plasma cells (PCs) and promoting T cell responses via antigen presentation, they perform immunoregulatory functions. This knowledge has created concerns regarding nonspecific B cell depletional therapy because of the potential to paradoxically augment immune responses. Recent studies now indicate that PCs have immune functions beyond immunoglobulin synthesis. Evidence for a new role for PCs as potent regulatory cells (via IL‐10 and IL‐35 production) is discussed including the implications for PC‐targeted therapies currently being developed for clinical transplantation.</p> </sec> </abstract>