Staphylococcus caprae bone and joint infections: a re‐emerging infection?. (29th July 2014)

• Record Type: Journal Article
• Authors: Seng, P.; Barbe, M.; Pinelli, P. O.; Gouriet, F.; Drancourt, M.; Minebois, A.; Cellier, N.; Lechiche, C.; Asencio, G.; Lavigne, J. P.; Sotto, A.; Stein, A.; Grobusch, M.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 12(2014:Dec.)
• Page Start: O1052
• Page End: O1058
• Publication Date: 2014-07-29
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12743
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12743-abs-0001"> <title>Abstract</title> <p> <italic>Staphylococcus caprae</italic> has been recently classified as a human pathogen, but the incidence of <italic>S. caprae</italic> in human bone and joint infections (BJIs) is under‐reported. In this study, we report 25 cases of <italic>S. caprae </italic>BJI, and we review the 31 cases published in the literature. Molecular techniques and matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry improved the identification of clinically relevant <italic>S. caprae</italic> strains. In this study, 96% of <italic>S. caprae </italic>BJIs were localized to the lower limbs, and 88% of the cases involved orthopaedic device infections<italic>. S. caprae</italic> joint prosthesis infections (JPIs), internal osteosynthesis device infections (I‐ODIs) and BJIs without orthopaedic device infections were recorded in 60%, 28% and 12% of cases, respectively. Ten (40%) <italic>S. caprae </italic>BJIs were polymicrobial infections. These infections were associated with past histories of malignancy (p 0.024). Of the 14 bacterial species related to <italic>S. caprae </italic>BJI, 57% were staphylococci. I‐ODIs were significantly associated with polymicrobial infections (p 0.0068), unlike JPIs, which were monomicrobial infections (p 0.0344). Treatment with rifampicin and fluoroquinolone was recorded in 40% of cases. Surgical treatment was performed in 76% of cases, e.g. prosthesis removal (36%), osteosynthesis device removal (24%), and surgical debridement (16%). Thirty per cent of cases were not treated. Relapses were observed mainly in the patients treated by surgical debridement only (p 0.033). In summary, <italic>S. caprae </italic>BJI is an underestimated hospital‐acquired emerging infection. <italic>S. caprae </italic>BJI is correlated with infections in orthopaedic devices, which must be removed to control the infection.</p> </abstract>