Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain. Issue 1 (16th January 2014)

• Record Type: Journal Article
• Authors: Near, Jamie; Edden, Richard; Evans, C. John; Paquin, Raphaël; Harris, Ashley; Jezzard, Peter
• Is Part Of: Magnetic resonance in medicine. Volume 73:Issue 1(2015:Jan.)
• Page Start: 44
• Page End: 50
• Publication Date: 2014-01-16
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25094
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25094-sec-0001" sec-type="section"> <title>Purpose</title> <p>Frequency and phase drifts are a common problem in the acquisition of in vivo magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency and phase drifts will result in artifactual broadening of spectral peaks, distortion of spectral lineshapes, and a reduction in signal‐to‐noise ratio (SNR). We present herein a new method for estimating and correcting frequency and phase drifts in in vivo MRS data.</p> </sec> <sec id="mrm25094-sec-0002" sec-type="section"> <title>Methods</title> <p>We used a simple method of fitting each spectral average to a reference scan (often the first average in the series) in the time domain through adjustment of frequency and phase terms. Due to the similarity with image registration, this method is referred to as "spectral registration." Using simulated data with known frequency and phase drifts, the performance of spectral registration was compared with two existing methods at various SNR levels.</p> </sec> <sec id="mrm25094-sec-0003" sec-type="section"> <title>Results</title> <p>Spectral registration performed well in comparison with the other methods tested in terms of both frequency and phase drift estimation.</p> </sec> <sec id="mrm25094-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Spectral registration provides an effective method for frequency and phase drift correction. It does not involve the collection of navigator echoes, and does not rely on any specific resonances, such as residual water or creatine, making it highly versatile. Magn Reson Med 73:44–50, 2015. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>