Back Cover: [3H]UR‐DE257: Development of a Tritium‐Labeled Squaramide‐Type Selective Histamine H2 Receptor Antagonist (ChemMedChem 1/2015). Issue 1 (January 2015) - Baumeister, Paul
Abstract The back cover picture shows [3H]UR‐DE257, a tritium‐labeled selective histamine H2 receptor (H2R) antagonist identified from a series of piperidinomethylphenoxypropylamines. [3H]UR‐DE257 exhibits high specific binding and comparable Kd values at the human, rat, and guinea pig H2R. Despite insurmountable antagonism in functional studies and slow dissociation, it is fully displaceable in competition binding studies. Thus, [3H]UR‐DE257 is a valuable tool for the study of H2R. For more details, see the Full Paper by Armin Buschauer et al. on p. 83 ff.