High‐fat diet‐induced met‐hemoglobin formation in rats prone (WOKW) or resistant (DA) to the metabolic syndrome: Effect of CoQ10 supplementation. (27th November 2014)

• Record Type: Journal Article
• Authors: Orlando, Patrick; Silvestri, Sonia; Brugè, Francesca; Tiano, Luca; Kloting, Ingrid; Falcioni, Giancarlo; Polidori, Carlo
• Is Part Of: BioFactors. Volume 40:Number 6(2014:Nov./Dec.)
• Page Start: 603
• Page End: 609
• Publication Date: 2014-11-27
• Subjects: Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1190
• Languages: English
• ISSNs: 0951-6433

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>The aim of this study was to evaluate the effects of a high‐fat diet (HFD) on oxidative indexes in WistarOttawaKarlsburg W (WOKW) rats used as a model of metabolic syndrome in comparison with Dark Agouti (DA) rats used as a control strain. This syndrome is defined by the occurrence of two or more risk factors including obesity, hypertension, dyslipidemia, and insulin resistance. Forty rats were used in the study and the effect of HFD was evaluated in terms of body weight and both hemoglobin and CoQ oxidative status. Moreover, 16 rats (8 of each strain) were supplemented with 3 mg/100 g b.w. of CoQ₁₀ for 1 month in view of its beneficial properties in cardiovascular disease due to its antioxidant activity in the lipid environment. HFD promoted an increase in body weight, in particular in WOKW males, and in the methemoglobin (met‐Hb) index in both strains. Moreover, HFD promoted endogenous CoQ₁₀ oxidation. CoQ₁₀ supplementation was able to efficiently counteract the HFD pro‐oxidant effects, preventing met‐Hb formation and CoQ oxidation. © 2014 BioFactors, 40(6):603–609, 2014</p> </abstract>