Hepatitis C transmission from viremic donors in hematopoietic stem cell transplant. Issue 6 (4th November 2014)

• Record Type: Journal Article
• Authors: Hsiao, H.‐H.; Liu, Y.‐C.; Wang, H.‐C.; Wu, C.‐H.; Cho, S.‐F.; Hsu, J.‐F.; Tsai, H.‐J.; Hsiao, S.Y.; Chang, C.‐S.; Lin, S.‐F.; Liu, T.‐C.; Chuang, W.‐L.; Yu, M.‐L.
• Is Part Of: Transplant infectious disease. Volume 16:Issue 6(2014)
• Page Start: 1003
• Page End: 1006
• Publication Date: 2014-11-04
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12306
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12306-abs-0001"> <title>Abstract</title> <p>Transmission of hepatitis C virus (HCV) to recipients of hematopoietic stem cell transplant (HSCT) occurs frequently from HCV viremic donors and causes complications. Here, we report the outcomes of 3 cases from our 265 allogeneic HSCTs, whose donors had HCV infections. Successful prevention of HCV transmission was noted in 1 recipient by pretreatment of the donor with peginterferon/ribavirin to undetectable levels of HCV viremia before stem cell harvest. This case stressed the important role of effective antiviral therapy and HCV RNA seronegativity before cell harvest for prevention of HCV transmission in HSCT.</p> </abstract>