Results after the adoption of a MELD/PELD‐based liver allocation policy in Argentina. (21st November 2014)

• Record Type: Journal Article
• Authors: Dip, Marcelo; Cejas, Nora; Cervio, Guillermo; Villamil, Federico; Tagliafichi, Viviana; Hansen Krogh, Daniela; Imventarza, Oscar; Soratti, Carlos; Bisigniano, Liliana
• Is Part Of: Pediatric transplantation. Volume 19:Number 1(2015:Feb.)
• Page Start: 56
• Page End: 61
• Publication Date: 2014-11-21
• Subjects: Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.12395
• Languages: English
• ISSNs: 1397-3142

Abstract

<abstract abstract-type="main" id="petr12395-abs-0001"> <title>Abstract</title> <p>In July 2005, Argentina switched from a categorical liver allocation system to a MELD/PELD‐based policy for patients with CLD. To analyze WL outcomes and survival after LT in children. From January 2000 to December 2010, 923 children were registered. Two consecutive five‐yr periods were analyzed and compared: Era I (January 2000–July 2005) (n = 379) and Era II (July 2005–December 31, 2010) (n = 544). All data were prospectively collected and analyzed using the Kaplan–Meier method. After adopting the MELD/PELD system, WL registrations increased by 44% (from 379 to 544) and the number of LT increased by only 24% (from 278 to 365). However, three‐month WL mortality rate (32% to 18%, p &lt; 0.0001, HR 2.002 CI 95% 1.5–2.8) decreased significantly. No significant differences were observed between Era 1 and II in one‐yr post‐LT survival (77.5% vs. 84.1%, p = 0.3053) and in acute re‐LT rate (9% vs. 5%, p = 0.1746). Under the MELD/PELD‐based allocation system in Argentina, mortality on the WL significantly decreased in children with CLD without affecting post‐LT survival, although reduced access to LT was observed.</p> </abstract>