Transient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations. Issue 2 (30th August 2014)

• Record Type: Journal Article
• Authors: Nakashima, Megan O.; Shetty, Shashirekha; Chicka, Michael; Flagg, Aron; Eng, Charis; Cotta, Claudiu V.
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 2(2015:Feb.)
• Page Start: 353
• Page End: 355
• Publication Date: 2014-08-30
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25226
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc25226-sec-0001" sec-type="section"> <p>Transient abnormal myelopoiesis (TAM) is a disorder of Down syndrome newborns characterized by megakaryocytic blasts indistinguishable from acute myeloid leukemia (AML), which undergoes spontaneous remission. Acquired <italic>GATA1</italic> mutations are present in blasts of both TAM and the subsequent AML which sometimes develops. We present a unique case of a newborn with leukemic megakaryoblasts indistinguishable from those of TAM who had neither extra material from chromosome 21 in the germline or blasts, nor evidence of <italic>GATA1</italic> mutations. These findings suggest there are other genetic abnormalities that can lead to TAM besides <italic>GATA1</italic> mutation in the setting of trisomy 21. Pediatr Blood Cancer 2015;62:353–355. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>