Weight loss decreases follicle stimulating hormone in overweight postmenopausal women. (8th October 2014)

• Record Type: Journal Article
• Authors: Kim, Catherine; Randolph, John F.; Golden, Sherita H.; Labrie, Fernand; Kong, Shengchun; Nan, Bin; Barrett‐Connor, Elizabeth
• Is Part Of: Obesity. Volume 23:Number 1(2015:Jan.)
• Page Start: 228
• Page End: 233
• Publication Date: 2014-10-08
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20917
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20917-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause.</p> </sec> <sec id="oby20917-sec-0002" sec-type="section"> <title>Methods</title> <p>Participants were postmenopausal, overweight, glucose‐intolerant women not using exogenous estrogen (<italic>n</italic> = 382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 min per week of moderate‐intensity exercise, metformin 850 mg twice a day, or placebo administered twice a day.</p> </sec> <sec id="oby20917-sec-0003" sec-type="section"> <title>Results</title> <p>Randomization to ILS led to small increases in FSH between baseline and 1‐year follow‐up vs. placebo (2.3 IU/l vs. −0.81 IU/l, <italic>P</italic> < 0.01). Increases in FSH were correlated with decreases in weight (<italic>r</italic> = −0.165, <italic>P</italic> < 0.01) and estradiol (E2) (<italic>r</italic> = −0.464, <italic>P</italic> < 0.0001) after adjustment for age, race/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non‐significant changes in FSH and E2 levels vs. placebo.</p> </sec> <sec id="oby20917-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways.</p> </sec> </abstract>