Effects of intensive lifestyle intervention and gastric bypass on aortic stiffness: A 1‐year nonrandomized clinical study. (30th August 2014)

• Record Type: Journal Article
• Authors: Gjevestad, Espen; Hjelmesæth, Jøran; Sandbu, Rune; Nordstrand, Njord
• Is Part Of: Obesity. Volume 23:Number 1(2015:Jan.)
• Page Start: 37
• Page End: 45
• Publication Date: 2014-08-30
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20880
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20880-sec-0001" sec-type="section"> <title>Objective</title> <p>To compare the long‐term effects of Roux‐en‐Y gastric bypass (GBS) and intensive lifestyle intervention (ILI) on aortic stiffness.</p> </sec> <sec id="oby20880-sec-0002" sec-type="section"> <title>Methods</title> <p>Nonrandomized clinical trial. Aortic stiffness was assessed by carotid‐femoral pulse wave velocity (<sub>cf</sub>PWV) using high‐fidelity applanation tonometry.</p> </sec> <sec id="oby20880-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 159 treatment‐seeking morbidly obese patients were included, 82 (54 females) in the GBS‐group and 77 (48 females) in the ILI‐group. Participants in the GBS‐group were younger (42.0 ± 9.9 vs. 46.4 ± 10.5 years), heavier (BMI 45.7 ± 5.3 vs. 42.0 ± 4.9 kg/m<sup>2</sup>), and had lower systolic pressure (137 ± 19 vs. 145 ± 18 mm Hg) and pulse pressure (57 ± 16 vs. 65 ± 17 mm Hg), all <italic>P</italic> ≤ 0.006. Mean (SD) <sub>cf</sub>PWV at baseline was 8.6 ± 1.7 m/s in the GBS‐group and 8.6 ± 1.9 m/s in the ILI‐group, <italic>P</italic> = 0.959. At follow‐up, mean (95% CI) weight loss was larger in the GBS‐group than in the ILI‐group −43.3 (−46.0 to −40.7) vs. −12.1 (−14.6 to −9.6) kg, <italic>P</italic> < 0.001. The mean change in <sub>cf</sub>PWV was −0.02 (−0.31 to 0.27) m/s in the GBS‐group and 0.03 (−0.28 to 0.33) m/s in the ILI‐group, both <italic>P</italic> ≥ 0.412; adjusted between‐group difference (ANCOVA) 0.05 (−0.40 to 0.49) m/s, <italic>P</italic> = 0.836. The adjusted regression analysis showed that weight loss was associated with increased <sub>cf</sub>PWV in the GBS‐group.</p> </sec> <sec id="oby20880-sec-0004" sec-type="section"> <title>Conclusions</title> <p>GBS and ILI had no significant long‐term effects on aortic stiffness in treatment‐seeking morbidly obese individuals.</p> </sec> </abstract>