Usefulness of optical coherence tomography to detect central serous chorioretinopathy in monkeys. Issue 2 (28th March 2014)

• Record Type: Journal Article
• Authors: Park, Hyun‐Kyu; Jo, Woori; Choi, Hyun‐Ji; Kim, Bongcheol; Lee, Gilnam; Seo, Jeongbeob; Cho, Suk Young; Kim, Choung‐Soo; Choi, Eun Kyung; Hwang, Jung Jin; Lee, Joo Yong; Yoon, Young Hee; Son, Woo‐Chan
• Is Part Of: Journal of applied toxicology. Volume 35:Issue 2(2015)
• Page Start: 199
• Page End: 204
• Publication Date: 2014-03-28
• Subjects: Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.3009
• Languages: English
• ISSNs: 0260-437X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Many systemic drugs can induce ocular toxicity and several ocular side‐effects have been identified in clinical studies. However, it is difficult to detect ocular toxicity in preclinical studies because of the lack of appropriate evaluation methods. Optical coherence tomography (OCT) is useful because it can provide real‐time images throughout a study period, whereas histopathology only provides images of sacrificed animals. Using OCT alongside histopathology, attempts were made to find effective approaches for screening of drug‐induced ocular toxicity in monkeys. Such approaches could be used in preclinical studies prior to human trials. Six male cynomolgus monkeys (<italic>Macaca fascicularis Raffles</italic>) were orally administered one of six candidate MAPK/ERK kinase (MEK) inhibitors. Central serous chorioretinopathy, a known side‐effect of such inhibitors, was identified in four monkeys by OCT. Artifacts generated during tissue processing meant that histopathology could not detect edematous changes. Thus, OCT is a useful tool to detect ocular toxicity which cannot be detected by histopathology in preclinical studies. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>