Stable but Reactive Perfluoroalkylzinc Reagents: Application in Ligand‐Free Copper‐Catalyzed Perfluoroalkylation of Aryl Iodides. Issue 1 (13th November 2014)

• Record Type: Journal Article
• Authors: Aikawa, Kohsuke; Nakamura, Yuzo; Yokota, Yuki; Toya, Wataru; Mikami, Koichi
• Is Part Of: Chemistry. Volume 21:Issue 1(2015)
• Page Start: 96
• Page End: 100
• Publication Date: 2014-11-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201405677
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The aromatic perfluoroalkylation catalyzed by a copper(I) salt with bis(perfluoroalkyl)zinc reagents Zn(R_F)₂(DMPU)₂, which were prepared and then isolated as a stable white powder from perfluoroalkyl iodide and diethylzinc, was accomplished to provide the perfluoroalkylated products in good‐to‐excellent yields. The advantages of this reliable and practical catalytic reaction are 1) air‐stable and easy‐to‐handle bis(perfluoroalkyl)zinc reagents can be utilized, 2) the reagent is reactive and hence the operation without activators and ligands is simple, and 3) not only trifluoromethylation but also perfluoroalkylation can be attained.</p> </abstract>