The Effect of Intravitreal Anti-VEGF on the Pigment Epithelial Detachment in Eyes with the Exudative Type of Age-Related Macular Degeneration. (January 2015)

• Record Type: Journal Article
• Authors: Kalouda, Pelagia; Anastasakis, Anastasios; Tsika, Chrysanthi; Tsilimbaris, K. Miltiadis
• Is Part Of: Seminars in ophthalmology. Volume 30:Number 1(2015)
• Page Start: 6
• Page End: 10
• Publication Date: 2015-01
• Subjects: Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Surgery -- Periodicals; 617.7005
• DOI: 10.3109/08820538.2013.807852
• Languages: English
• ISSNs: 0882-0538

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: To evaluate the effect of anti-VEGF treatment on pigment epithelial detachment (PED) secondary to the exudative type of age-related macular degeneration (AMD). <italic>Methods</italic>: Retrospective analysis of 30 eyes (28 patients) with exudative AMD accompanied by PED (receiving anti-VEGF injections). Alterations of the PED morphology were qualitatively assessed with optical coherence tomography (OCT). Changes in best-corrected visual acuity (BCVA) and number of injections were compared to 30 control eyes (30 patients) exhibiting exudative AMD without PED. <italic>Results</italic>: Mean follow-up was 19.8 months. Changes of the extent of PED were as follows: unchanged: 11 eyes (36.7%); reduced: 12 (40%); significantly reduced: 7 (23.3%). Mean paired difference in BCVA was −0.08 logMAR (<italic>p</italic> = 0.46) and in the number of injections was 2.1 injections (<italic>p</italic> = 0.04). <italic>Conclusions</italic>: A substantial number of the studied patients showed reduction of the extent of the PED after anti-VEGF treatment. The PED group required a higher number of injections.</p> </abstract>