Similar dynamics of intraapheresis autologous CD34+ recruitment and collection efficiency in patients undergoing mobilization with or without plerixafor. Issue 12 (19th June 2014)

• Record Type: Journal Article
• Authors: Schade, Henning; Chhabra, Saurabh; Kang, Yubin; Stuart, Robert K.; Edwards, Kathy H.; Kramer, Cindy; Butcher, Coleen; Littleton, Amanda; Schneider, Molly; Budisavljevic, Milos N.; Costa, Luciano J.
• Is Part Of: Transfusion. Volume 54:Issue 12(2014)
• Page Start: 3131
• Page End: 3137
• Publication Date: 2014-06-19
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12761
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12761-sec-0001" sec-type="section"> <title>Background</title> <p>Compared with growth factor (G) alone, the combination of G with plerixafor (G + P) increases peripheral blood CD34+ count (PB‐CD34+) and improves CD34+ collection yield (yCD34+) in multiple myeloma and lymphoma patients undergoing autologous hematopoietic progenitor cell (AHPC) mobilization. It is unknown whether the improved yCD34+ with G + P results entirely from expansion of PB‐CD34+ or also from increased intraapheresis CD34+ recruitment and collection efficiency.</p> </sec> <sec id="trf12761-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>We retrospectively studied 192 patients who underwent AHPC mobilization and collection with G (n = 73) or G + P (n = 119) to compare the adjusted relative efficiency (aRE), the proportion of the circulating CD34+ pool that is captured for each blood volume processed. Additionally, in a prospective cohort of nine patients mobilizing with G and 11 with G + P, PB‐CD34+ after leukapheresis allowed calculation of the recruitment coefficient (RC), proportion of the initial CD34+ pool recruited from the marrow into peripheral blood for each blood volume processed.</p> </sec> <sec id="trf12761-sec-0003" sec-type="section"> <title>Results</title> <p>There was no difference in aRE between G and G + P (0.50 vs. 0.46; p = 0.37) and no substantial decline in aRE with higher blood volumes processed in either group. RC was also not different between G and G + P (median, 0.39 and 0.38, respectively; p = 0.7). Prediction of yCD34+ was determined essentially by PB‐CD34+ and not affected independently by plerixafor.</p> </sec> <sec id="trf12761-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Kinetics of intraapheresis CD34+ recruitment and collection is proportional to PB‐CD34+ but not influenced further by plerixafor.</p> </sec> </abstract>