PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose1. (21st October 2014)

• Record Type: Journal Article
• Authors: Ning, Xinghai; Seo, Wonewoo; Lee, Seungjun; Takemiya, Kiyoko; Rafi, Mohammad; Feng, Xuli; Weiss, Daiana; Wang, Xiaojian; Williams, Larry; Camp, Vernon M.; Eugene, Malveaux; Taylor, W. Robert; Goodman, Mark; Murthy, Niren
• Is Part Of: Angewandte Chemie. Volume 126:Number 51(2014)
• Page Start: 14320
• Page End: 14325
• Publication Date: 2014-10-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201408533
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A positron emission tomography (PET) tracer composed of ¹⁸F‐labeled maltohexaose (MH¹⁸F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose (¹⁸FDG). MH¹⁸F can detect early‐stage infections composed of as few as 10⁵<italic>E. coli</italic> colony‐forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH¹⁸F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.</p> </abstract>