Predictive value of gelsolin for the outcomes of preterm neonates: A pilot study. Issue 6 (10th November 2014)

• Record Type: Journal Article
• Authors: Kose, Mehmet; Elmas, Tuba; Gokahmetoglu, Selma; Ozturk, Mehmet Adnan; Ekinci, Duygu; Elmali, Ferhan; Halis, Hulya; Bastug, Osman
• Is Part Of: Pediatrics international. Volume 56:Issue 6(2014)
• Page Start: 856
• Page End: 859
• Publication Date: 2014-11-10
• Subjects: Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12391
• Languages: English
• ISSNs: 1328-8067

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ped12391-sec-0001" sec-type="section"> <title>Background</title> <p>Plasma gelsolin is a circulating actin‐binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.</p> </sec> <sec id="ped12391-sec-0002" sec-type="section"> <title>Methods</title> <p>A total of 32 preterm neonates born at 23–32 weeks of gestation were enrolled in the study.</p> </sec> <sec id="ped12391-sec-0003" sec-type="section"> <title>Results</title> <p>Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (<italic>P</italic> &lt; 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (<italic>P</italic> &lt; 0.05).</p> </sec> <sec id="ped12391-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.</p> </sec> </abstract>