Computed tomography during hepatic arteriography pattern may predict hepatocellular carcinoma recurrence following transarterial chemoembolization. Issue 14 (6th May 2014)

• Record Type: Journal Article
• Authors: Katayama, Kazuhiro; Ohkawa, Kazuyoshi; Imanaka, Kazuho; Sakakibara, Mitsuru; Miyazaki, Masanori; Kimura, Haruki; Ishihara, Akio; Matsunaga, Takashi; Murata, Masayuki; Nakazawa, Tetsuro; Nakanishi, Katsuyuki
• Is Part Of: Hepatology research. Volume 44:Issue 14(2014)
• Page Start: E455
• Page End: E463
• Publication Date: 2014-05-06
• Subjects: Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12337
• Languages: English
• ISSNs: 1386-6346

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hepr12337-sec-0001" sec-type="section"> <title>Aim</title> <p>This study aimed to determine the role of morphological patterns seen on imaging in predicting hepatocellular carcinoma recurrence following transarterial chemoembolization therapy.</p> </sec> <sec id="hepr12337-sec-0002" sec-type="section"> <title>Methods</title> <p>Forty‐seven patients from a single center who underwent transarterial chemoembolization to treat unresectable hepatocellular carcinomas between January 2011 and June 2012 were included in this study. We investigated whether the two pretreatment findings on computed tomography during hepatic arteriography (pattern 1, the single nodule pattern; pattern 2, at least one nodule showing the contiguous multinodular pattern) and other factors (age, sex, etiology, serum total bilirubin, serum albumin, prothrombin time, platelet count, serum level of protein induced by vitamin K absence/antagonist‐II, serum α‐fetoprotein, number of previous treatments for hepatocellular carcinoma, tumor number and maximum tumor size, presence of hypovascular lesions) could predict post‐treatment recurrence.</p> </sec> <sec id="hepr12337-sec-0003" sec-type="section"> <title>Results</title> <p>In a univariate analysis using Cox's proportional hazards model, serum total bilirubin, the serum level of protein induced by vitamin K absence/antagonist‐II (≤100 vs ≥101 mAU/mL), tumor morphology (pattern 1 vs 2) and tumor number (≤3 vs ≥4) showed statistical significance (≤0.05). In a multivariate analysis of these factors, morphology and tumor number showed significance. According to Kaplan–Meier estimation, the cumulative disease‐free survival rates were significantly lower in patients with four or more lesions than in those with three or less lesions and in patients showing pattern 2 than in those showing pattern 1.</p> </sec> <sec id="hepr12337-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Patients with pattern 2 hepatocellular carcinoma and/or four or more lesions may have a relatively high recurrence rate after transarterial chemoembolization.</p> </sec> </abstract>