Ribosomal protein S6 is hyperactivated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis. (9th November 2014)

• Record Type: Journal Article
• Authors: Ruf, M.T.; Andreoli, A.; Itin, P.; Pluschke, G.; Schmid, P.
• Is Part Of: British journal of dermatology. Volume 171:Number 6(2014:Dec.)
• Page Start: 1533
• Page End: 1536
• Publication Date: 2014-11-09
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.13248
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd13248-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd13248-list-0001" list-type="bullet"> <list-item> <p>Phosphorylation of ribosomal protein S6 is important for the initiation of translation.</p> </list-item> <list-item> <p>S6 becomes phosphorylated via the mammalian target of rapamycin pathway, which is activated in psoriatic skin.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd13248-list-0002" list-type="bullet"> <list-item> <p>In psoriasis and atopic dermatitis, S6 phosphorylation is associated with inflammation and epidermal hyperproliferation.</p> </list-item> <list-item> <p>S6 is differentially phosphorylated in distinct layers of the diseased epidermis, which may impact on the proliferation/differentiation of keratinocytes.</p> </list-item> </list> </p> </abstract>