Simultaneous MRI of lung structure and perfusion in a single breathhold. Issue 1 (20th December 2013)

• Record Type: Journal Article
• Authors: Bell, Laura C.; Johnson, Kevin M.; Fain, Sean B.; Wentland, Andrew; Drees, Randi; Johnson, Rebecca A.; Bauman, Grzegorz; Francois, Christopher J.; Nagle, Scott K.
• Is Part Of: Journal of magnetic resonance imaging. Volume 41:Issue 1(2015)
• Page Start: 52
• Page End: 59
• Publication Date: 2013-12-20
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24520
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24520-sec-0001" sec-type="section"> <title>Purpose</title> <p>To develop and demonstrate a breathheld 3D radial ultrashort echo time (UTE) acquisition to visualize co‐registered lung perfusion and vascular structure.</p> </sec> <sec id="jmri24520-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Nine healthy dogs were scanned twice at 3 Tesla (T). Contrast‐enhanced pulmonary perfusion scans were acquired with a temporally interleaved three‐dimensional (3D) radial UTE (TE = 0.08 ms) sequence in a breathhold (1 s time frames over a 33 s breathhold). The 3D breathheld volume was reconstructed into time‐resolved perfusion datasets, and a composite vascular structure dataset. For structural comparison, a 5 min respiratory‐gated 3D radial UTE scan was acquired. Data were analyzed by quantitative metrics and radiologist scoring.</p> </sec> <sec id="jmri24520-sec-0003" sec-type="section"> <title>Results</title> <p>Appropriate time‐course of contrast was seen in all subjects. Right ventricle to aorta transit times were 7.4 ± 2.0 s. Relative lung enhancement was a factor of 8.4 ± 1.5. Radiologist scoring showed similarly excellent visualization of the pulmonary arteries to the subsegmental level in breathheld (94% of cases) and respiratory‐gated (100% of cases) acquisitions (<italic>P</italic> = 0.33) despite the aggressive under sampling in the breathheld scan. Similarly, differentiation of lung tissue and airways was achieved by both acquisition methods.</p> </sec> <sec id="jmri24520-sec-0004" sec-type="section"> <title>Conclusion</title> <p>A time‐resolved 3D radial UTE sequence for simultaneous imaging of pulmonary perfusion and co‐registered vascular structure is feasible. <bold>J. Magn. Reson. Imaging 2015;41:52–59.</bold> © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>