SYNTAX score and the risk of stent thrombosis after percutaneous coronary intervention in patients with non‐ST‐segment elevation acute coronary syndromes: An ACUITY trial substudy. Issue 1 (17th June 2014)

• Record Type: Journal Article
• Authors: Yadav, Mayank; Généreux, Philippe; Palmerini, Tullio; Caixeta, Adriano; Madhavan, Mahesh V.; Xu, Ke; Brener, Sorin J.; Mehran, Roxana; Stone, Gregg W.
• Is Part Of: Catheterization and cardiovascular interventions. Volume 85:Issue 1(2015:Jan. 01)
• Page Start: 1
• Page End: 10
• Publication Date: 2014-06-17
• Subjects: Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.25396
• Languages: English
• ISSNs: 1522-1946

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ccd25396-sec-0001" sec-type="section"> <title>Objective</title> <p>We sought to investigate the relationship between the SYNTAX score (SS) and stent thrombosis (ST) in patients with non‐ST‐segment elevation acute coronary syndromes (NSTE‐ACS) undergoing percutaneous coronary intervention (PCI).</p> </sec> <sec id="ccd25396-sec-0002" sec-type="section"> <title>Background</title> <p>The relationship between the SS and ST is undetermined.</p> </sec> <sec id="ccd25396-sec-0003" sec-type="section"> <title>Methods</title> <p>We stratified 2, 627 patients undergoing PCI in the ACUITY trial by SS tertile according to the current population (true tertiles, SS <7, SS = 7–12, and SS >12) and by the SYNTAX trial (original SYNTAX tertiles, SS <23, SS = 23–32, and SS >32). Thirty‐day and 1‐year rates of definite/probable ST were determined for each tertile.</p> </sec> <sec id="ccd25396-sec-0004" sec-type="section"> <title>Results</title> <p>A total 30 (1.1%) and 41 (1.6%) definite/probable ST events occurred by 30 days and 1 year, respectively. When stratified by true tertiles, 30‐day and 1‐year rates of definite/probable ST were significantly greater in the highest tertile (SS >12; 2.0% and 2.8%) compared with the intermediate (SS = 7–12; 0.7% and 1.1%) and lowest tertiles (SS <7; 0.6% and 0.7%), <italic>P</italic> = 0.007 and <italic>P</italic> = 0.0009, respectively. When stratified by original SYNTAX tertiles, 30‐day and 1‐year rates of definite/probable ST were significantly greater in the highest (SS >32; 6.3% and 8.8%) and intermediate tertiles (SS = 23–32; 2.8% and 3.7%) compared with the lowest tertile (SS < 22; 0.8% and 1.2%), <italic>P</italic> <0.0001 for both. By multivariable analysis, the SS was an independent predictor for both 30‐day and 1‐year definite/probable ST.</p> </sec> <sec id="ccd25396-sec-0005" sec-type="section"> <title>Conclusions</title> <p>In patients with NSTE‐ACS undergoing PCI, the extent and severity of CAD, as assessed by the SS before revascularization, was strongly associated with the occurrence of ST both at 30 days and 1 year. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>