A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins1. (10th November 2014)

• Record Type: Journal Article
• Authors: Qu, Bo; Samankumara, Lalith P.; Ma, Shengli; Fandrick, Keith R.; Desrosiers, Jean‐Nicolas; Rodriguez, Sonia; Li, Zhibin; Haddad, Nizar; Han, Zhengxu S.; McKellop, Keith; Pennino, Scott; Grinberg, Nelu; Gonnella, Nina C.; Song, Jinhua J.; Senanayake, Chris H.
• Is Part Of: Angewandte Chemie. Volume 126:Number 52(2014)
• Page Start: 14656
• Page End: 14660
• Publication Date: 2014-11-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201408929
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric hydrogenation of unfunctionalized 1‐aryl‐3, 4‐dihydronaphthalenes under one atmosphere pressure of H₂, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1‐tetralones.</p> </abstract>