Racemic DNA Crystallography1. (30th October 2014)

• Record Type: Journal Article
• Authors: Mandal, Pradeep K.; Collie, Gavin W.; Kauffmann, Brice; Huc, Ivan
• Is Part Of: Angewandte Chemie. Volume 126:Number 52(2014)
• Page Start: 14652
• Page End: 14655
• Publication Date: 2014-10-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201409014
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic‐protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of <sc>L</sc>‐ and <sc>D</sc>‐deoxyribo‐oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four‐way junction, showing that the advantages of racemic crystallography should extend to DNA.</p> </abstract>