Index pregnancy versus post-index pregnancy in patients with recurrent pregnancy loss. (January 2015)

• Record Type: Journal Article
• Authors: Greenberg, Tzlil; Tzivian, Liliana; Harlev, Avi; Serjienko, Ruslan; Mazor, Moshe; Bashiri, Asher
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 1(2015)
• Page Start: 63
• Page End: 67
• Publication Date: 2015-01
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.900752
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To compare pregnancy outcomes of two consecutive pregnancies in a cohort of women with recurrent pregnancy loss (RPL), in order to determine the long-term prognosis of women with RPL managed in a dedicated RPL clinic.</p> <p> <italic>Methods</italic>: A retrospective cohort study including 262 patients with two or more consecutive pregnancy losses followed by two subsequent pregnancies – index pregnancy (IP) and post-index pregnancy (PIP). All patients were evaluated and treated in the RPL clinic in the Soroka University Medical Center.</p> <p> <italic>Results</italic>: Comparing IP with PIP, no significant difference in perinatal outcome was observed. The perinatal outcome remained encouraging with approximately 73% birth rate (73.7% versus 72.5%; <italic>p</italic> = 0.83). Only 11% of the women with RPL continued to experience pregnancy losses for two subsequent pregnancies. In a multivariate logistic regression analysis, number of miscarriages pre-Index was the only factor independently associated with birth in the PIP.</p> <p> <italic>Conclusion</italic>: There is no significant difference between IP and PIP regarding perinatal outcome. Appropriate management in the RPL clinic conferred a significant beneficial effect on long-term pregnancy outcome of a cohort of women with RPL.</p> </abstract>