The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population. (January 2015)

• Record Type: Journal Article
• Authors: Zhan, Yi-Hong; Lin, Yi; Tong, Sui-Jun; Ma, Qi-Lin; Lu, Cong-Xia; Fang, Ling; Wei, Wei; Cai, Bin; Wang, Ning
• Is Part Of: Annals of human biology. Volume 42:Number 1(2015:Jan./Feb.)
• Page Start: 26
• Page End: 30
• Publication Date: 2015-01
• Subjects: Human biology -- Periodicals; 612
• DOI: 10.3109/03014460.2014.944214
• Languages: English
• ISSNs: 0301-4460

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals.</p> <p> <italic>Aim</italic>: The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population.</p> <p> <italic>Subjects and methods</italic>: This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS.</p> <p> <italic>Results</italic>: The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly (<italic>p</italic> &lt; 0.01) associated with IS. These associations remained after adjustment for age, gender, smoking status, hypertension, diabetes mellitus and hypercholesterolemia. In addition, a significant association was observed of rs6007897 and rs4044210 of CELSR1 with large artery atherosclerosis (LAA), a sub-type of IS (<italic>p</italic> &lt; 0.01).</p> <p> <italic>Conclusion</italic>: Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA.</p> </abstract>