Preterm birth in the first pregnancy and risk of neonatal death in the second pregnancy: A propensity score-weighted matching approach. (January 2015)

• Record Type: Journal Article
• Authors: Whiteman, V. E.; August, E. M.; Mogos, M.; Naik, E.; Garba, M.; Sanchez, E.; Weldeselasse, H. E.; Salihu, H. M.
• Is Part Of: Journal of obstetrics and gynaecology. Volume 35:Number 1(2015)
• Page Start: 30
• Page End: 36
• Publication Date: 2015-01
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.3109/01443615.2014.937328
• Languages: English
• ISSNs: 0144-3615

Abstract

<abstract> <title>Abstract</title> <p>The study purpose was to assess the relationship between various grades of preterm birth (moderate preterm: 33–36 weeks; severe preterm: 27–32 weeks; extreme preterm: ≤ 26 weeks) in the first pregnancy and neonatal mortality (death within 28 days of birth; early: 0–7 days; late: 8–28 days) in the second pregnancy. Using the Missouri maternally-linked dataset (1989–2005), a population-based, retrospective cohort analysis with propensity score-weighted matching was conducted on mothers with two consecutive singleton live births (<italic>n</italic> = 310, 653 women). Women with a prior preterm birth were more likely to subsequently experience neonatal death. The odds increased in a dose-dependent pattern with ascending severity of the preterm event in the first pregnancy (moderate preterm: AOR = 1.32; 95% CI: 1.10–1.60; severe preterm: AOR = 2.62; 95% CI: 2.01–3.41; extreme preterm: AOR = 5.84; 95% CI: 4.28–7.97; <italic>p</italic> value for trend &lt; 0.001). However, the pathway for the relationship between prior preterm birth and subsequent neonatal mortality may be the recurrence of preterm birth.</p> </abstract>