Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end‐stage renal disease. (21st August 2014)

• Record Type: Journal Article
• Authors: Lin, C.‐H.; Sy, H.‐N.; Chang, H.‐W.; Liou, H.‐H.; Lin, C.‐Y.; Wu, V.‐C.; Wu, S.‐L.; Chang, C.‐C.; Chiu, P.‐F.; Li, W.‐Y.; Lin, S.‐Y.; Wu, K.‐D.; Chen, Y.‐M.; Wu, R.‐M.
• Is Part Of: European journal of neurology. Volume 22:Number 1(2015:Jan.)
• Page Start: 142
• Page End: 149
• Publication Date: 2014-08-21
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12545
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12545-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12545-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Earlier studies suggested an association between idiopathic restless legs syndrome (RLS) and cardiovascular diseases. However, the risk of cardiovascular events in patients with secondary RLS due to end‐stage renal disease (ESRD) is unclear. Our aim was to examine whether ESRD patients with RLS had an increased risk of cardio/cerebrovascular events and mortality.</p> </sec> <sec id="ene12545-sec-0002" sec-type="section"> <title>Methods</title> <p>In all, 1093 ESRD patients were recruited between 2009 and 2010. The diagnosis and severity of RLS were assessed in a face‐to‐face interview. The occurrence of cardio/cerebrovascular events and death were confirmed by medical record review. The association between RLS and the outcomes of interest was examined using an adjusted multivariate Cox regression model.</p> </sec> <sec id="ene12545-sec-0003" sec-type="section"> <title>Results</title> <p>After a mean follow‐up period of 3.7 ± 0.8 years, ESRD patients with RLS had a significantly higher risk of developing cardiovascular events and strokes [adjusted hazard ratio (aHR) 2.82, 95% confidence interval (CI) 2.02–4.11, and aHR 2.41, 95% CI 1.55–3.75, respectively] compared with patients without RLS. Increasing RLS severity was associated with an increasing likelihood of cardiovascular events [mild RLS severity, aHR 1.71 (95% CI 1.02–2.87); moderate, 2.79 (1.64–4.66); severe, 2.85 (1.99–4.46)] and strokes [mild, 1.89 (0.87–4.16); moderate, 2.42 (1.50–3.90); severe, 2.64 (1.49–4.91)] in a dose‐dependent manner. RLS also increased the risk of total mortality in patients with ESRD [aHR 1.53 (95% CI 1.07–2.18), <italic>P </italic>=<italic> </italic>0.02]; this association attenuated slightly after stratification by individual RLS severity category [mild RLS severity, aHR 1.44 (95% CI 0.78–2.67); moderate, 1.49 (0.98–2.55); severe, 2.03 (0.93–4.45)].</p> </sec> <sec id="ene12545-sec-0004" sec-type="section"> <title>Conclusions</title> <p>ESRD patients with RLS demonstrated an increased likelihood of cardio/cerebrovascular events and mortality.</p> </sec> </abstract>