Novel bioresorbable strontium hydroxyapatite membrane for guided bone regeneration. Issue 1 (5th November 2013)

• Record Type: Journal Article
• Authors: Hao, J.; Acharya, A.; Chen, K.; Chou, J.; Kasugai, S.; Lang, N. P.
• Is Part Of: Clinical oral implants research. Volume 26:Issue 1(2015:Jan.)
• Page Start: 1
• Page End: 7
• Publication Date: 2013-11-05
• Subjects: Dental implants -- Research -- Periodicals; 617.69
• DOI: 10.1111/clr.12289
• Languages: English
• ISSNs: 0905-7161

Abstract

<abstract abstract-type="main" id="clr12289-abs-0001"> <title>Abstract</title> <sec id="clr12289-sec-0001" sec-type="section"> <title>Objectives</title> <p>Membrane materials have been widely used for guided bone regeneration (GBR). However, due to bio‐functional limitation of the current membranes, the ideal resorbable membrane that can stimulate bone regeneration has yet to be developed. This study seeks to investigate the effects of a strontium hydroxyapatite (SrHA)‐containing membrane for GBR.</p> </sec> <sec id="clr12289-sec-0002" sec-type="section"> <title>Material and methods</title> <p>Strontium hydroxyapatite powder was synthesized and mixed with gelatin solution to the final concentration of 10 mg/ml (Sr10) and 20 mg/ml (Sr20). Approximately 100‐μm‐thick membranes were fabricated, and the mechanical properties and strontium ion release pattern were analyzed. Rat bone marrow stromal cell (BMSC) responses were investigated <italic>in vitro</italic>. Bilaterial rat calvarial defects were used <italic>in vivo</italic> to compare the SrHA membranes against commercially available collagen membranes and evaluated radiologically and histologically.</p> </sec> <sec id="clr12289-sec-0003" sec-type="section"> <title>Results</title> <p>Strontium hydroxyapatite membranes exhibited higher elasticity and strength than the collagen membrane, and slow strontium ion release was also confirmed. No BMSC cytotoxicity was found on the SrHA membranes, and the alkaline phosphatase positively stained area was significantly greater than the collagen membrane at earlier time point. At 4 weeks, both micro‐CT and histological analyses revealed that the Sr20 group yielded significantly greater bone formation.</p> </sec> <sec id="clr12289-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The SrHA‐containing membrane developed in this study was found to be a biocompatible material that can stimulate BMSC differentiation as well as bone regeneration and maturation in rat calvarial defects at early time point compared with collagen membrane. The best result was observed in Sr20 group, which can be potentially effective for GBR.</p> </sec> </abstract>