The Isolation of Antiprotozoal Compounds from Libyan Propolis. (9th July 2014)

• Record Type: Journal Article
• Authors: Siheri, Weam; Igoli, John O.; Gray, Alexander I.; Nasciemento, Ticiano G.; Zhang, Tong; Fearnley, James; Clements, Carol J.; Carter, Katharine C.; Carruthers, John; Edrada‐Ebel, RuAngelie; Watson, David G.
• Is Part Of: Phytotherapy research. Volume 28:Number 12(2014:Dec.)
• Page Start: 1756
• Page End: 1760
• Publication Date: 2014-07-09
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5194
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Propolis is increasingly being explored as a source of biologically active compounds. Until now, there has been no study of Libyan propolis. Two samples were collected in North East Libya and tested for their activity against <italic>Trypanosoma brucei</italic>. Extracts from both samples had quite high activity. One of the samples was fractionated and yielded a number of active fractions. Three of the active fractions contained single compounds, which were found to be 13‐epitorulosal, acetyl‐13‐epi‐cupressic acid and 13‐epi‐cupressic acid, which have been described before in Mediterranean propolis. Two of the compounds had a minimum inhibitory concentration value of 1.56 µg/mL against <italic>T</italic>. <italic>brucei</italic>. The active fractions were also tested against macrophages infected with <italic>Leishmania donovani</italic>, and again moderate to strong activity was observed with the compounds having IC₅₀ values in the range 5.1–21.9 µg/mL. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>