Positively Charged Thermoresponsive Nanogels for Anticancer Drug Delivery. Issue 24 (14th August 2014)

• Record Type: Journal Article
• Authors: Molina, Maria; Giulbudagian, Michael; Calderón, Marcelo; Lendlein, Andreas; Behl, Marc
• Is Part Of: Macromolecular chemistry and physics. Volume 215:Issue 24(2014:Dec.)
• Page Start: 2414
• Page End: 2419
• Publication Date: 2014-08-14
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201400286
• Languages: English
• ISSNs: 1022-1352

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Thermoresponsive nanogels (NGs) are often used as smart nanocarriers for delivering bioactive molecules. Copolymerization of monomers with different functionalities is a well‐known technique that enables the tuning of their properties. Here, the synthesis of positively charged thermoresponsive NGs is reported, based on (<italic>N</italic>‐isopropylacrylamide) (NIPAM) as a thermoresponsive monomer, 2‐dimethyl(aminoethyl) methacrylate (DMAEM) as a charged comonomer, and dendritic acrylated polyglycerol (dPG) as a macro‐crosslinker. The NGs are characterized in terms of size, <italic>Z</italic> potential, and transition temperature. In order to evaluate its potential for anticancer therapy, the encapsulation and release of anticancer drugs such as doxorubicin (DOXO) and methotrexate (MTX) are tested. A high drug loading capacity and release rate make these NGs promising nanocarriers for biomedical applications. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2sxbhc2d" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>