Cytotoxic (9βH)‐Pimarane and (9βH)‐17‐Norpimarane Diterpenes from the Tuber of Icacina trichantha. Issue 12 (December 2014)

• Record Type: Journal Article
• Authors: Monday Onakpa, Michael; Zhao, Ming; Gödecke, Tanja; Chen, Wei‐Lun; Che, Chun‐Tao; Santarsiero, Bernard D.; Swanson, Steven M.; Uzoma Asuzu, Isaac
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 12(2014:Dec.)
• Page Start: 1914
• Page End: 1922
• Publication Date: 2014-12
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201400151
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Three (9<italic>βH</italic>)‐pimaranes, <bold>1, 2</bold>, and <bold>3</bold>, and two (9<italic>βH</italic>)‐17‐norpimaranes, <bold>4</bold> and <bold>5</bold>, belonging to a rare compound class in nature, were obtained from the tubers of <italic>Icacina trichantha</italic> for the first time. Compound <bold>1</bold> is a new natural product, and <bold>2</bold>–<bold>5</bold> have been previously reported. The structures were elucidated based on NMR and MS data, and optical rotation values. The absolute configurations of (9<italic>βH</italic>)‐pimaranes were unambiguously established based on X‐ray crystallographic analysis. Full NMR signal assignments for the known compounds <bold>2, 4</bold>, and <bold>5</bold>, which were not available in previous publications, are also reported. All five isolates displayed cytotoxic activities on MDA‐MB‐435 cells (<italic>IC</italic>₅₀ 0.66–6.44 μ<sc>M</sc>), while <bold>2, 3</bold>, and <bold>4</bold> also exhibited cytotoxicities on HT‐29 cells (<italic>IC</italic>₅₀ 3.00–4.94 μ<sc>M</sc>).</p> </abstract>