High‐resolution melting assay for genotyping of IFNL4‐associated dinucleotide variant rs368234815. (15th May 2014)

• Record Type: Journal Article
• Authors: Galmozzi, E.; Facchetti, F.; Perbellini, R.; Aghemo, A.; Antonelli, G.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 11(2014:Nov.)
• Page Start: O936
• Page End: O938
• Publication Date: 2014-05-15
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12637
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12637-abs-0001"> <title>Abstract</title> <p>Interferon‐λ4‐related dinucleotide variant rs368234815 TT/‐G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment‐induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high‐resolution melting genotyping assay using 193 patients with chronic hepatitis C.</p> </abstract>